The P.L.E.A.S.E.® device is the new robust technology which enables the delivery of bio-active agents of large molecular size to dermal layers. The P.L.E.A.S.E.® device creates micro-pores of the desired size and depth almost painlessly. The creation of these channel-like pores happens without any significant trauma allowing the bio-active agent to permeate lateral and downwards into the tissue.
In a study carried out in Copenhagen to assess the efficacy and safety of ablative fractional laser-assisted daylight photodynamic therapy (AFL-dPDT) for treatment of actinic keratosis in organ transplant recipients, pain was assessed using a numerical rating scale (whereby 0 = no pain and 10 = worst pain imaginable) and long-term skin changes were evaluated.
Less carbonization and thus minimal coagulation may not only result in shorter healing times and a significantly lower risk of hypopigmentation, they also create a highly-effective passage for drug delivery. The char-free micropores enable a better uptake of substances, even large molecular size drugs.
Confocal images showing the distribution of FITC fluorescence in the (left) XY- and (right) XZ-planes following P.L.E.A.S.E® poration of full thickness porcine skin.
Both pore density and pore depth may play an important role in immunogen delivery. The ability to adjust both parameters via the user-friendly touchscreen allows for controlled delivery of the desired dosage to targeted skin layers.
A higher number and therefore higher density of micropores will increase the efficiency of delivery, which can be seen in the cumulative permeation of the drug into the skin.