January 17, 2013

P.L.E.A.S.E.® Laser Device Suitable for Painless Antigen Application - Promising results published in three different papers


Ruggell, Liechtenstein, January 17, 2013 - Pantec Biosolutions AG, the manufacturer of P.L.E.A.S.E.® Professional, a portable laser device for the precise microporation of the skin, has contributed to three scientific publications illustrating the effectiveness of the technology for a new form of immunotherapy in an allergic asthma mouse model.


The three papers focus on different aspects of Pantec Biosolutions’ work with P.L.E.A.S.E.® in immunotherapy and are published in Vaccine[1]Allergy[2] and the Journal of Controlled Release[3] .

The Pantec P.L.E.A.S.E.® (Precise laser epidermal system) device was used by Prof. Josef Thalhamer, Dr Richard Weiss and co-workers from the University of Salzburg in a transcutanoeous immunotherapy (TCIT) protocol to treat allergic mice. The curing effect of TCIT with P.L.E.A.S.E.® was comparable to the standard treatment: subcutaneous immunotherapy (SCIT) using needle-injection. In contrast to SCIT, TCIT is absolutely painless and minimises inflammatory side effects.


Conventional SCIT starts with 12-16 subcutaneous needle injections of increasing doses of allergen, followed by monthly injections of the maintenance dose over 2-3 years. The high volume of painful needle applications and unpleasant side effects are major reasons why patient compliance is often low over the long period required for a successful allergy treatment. TCIT with P.L.E.A.S.E.® offers a painless alternative.

Dr Christof Boehler, the CEO of Pantec Biosolutions, said: “I am delighted that our P.L.E.A.S.E.® technology has been successfully used in this series of experiments. The results provide strong evidence that antigen delivery to the correct dermal layer works effectively.”


Prof. Josef Thalhamer, co-author of the three papers, commented: “SCIT treatment can be a lengthy and uncomfortable experience resulting in decreasing patient compliance over the long time period necessary for a successful allergy treatment. Painless TCIT using P.L.E.A.S.E.® combined with individual allergy patches could replace the SCIT in the future leading to an increase in completed treatment regimens.”

If you are interested in finding out more information about Pantec Biosolutions’ P.L.E.A.S.E.® Professional system, please visit www.please-professional.com or the Company’s homepage: www.pantec-biosolutions.com


Company contact: Pantec Biosolutions AG                        
Media contact: College Hill Life Sciences

Dr Christof Böhler
Board Member
t:  +423 377 7800
e: christof.boehler(at)pantec-biosolutions.com


Dr Robert Mayer
Account Director
College Hill Life Sciences
t:  +49 (0)89 52 38 80 30
e: robert.mayer(at)collegehill.com       


[1] Hessenberger M, et al. Transcutaneous delivery of CpG-adjuvanted allergen via laser-generated micropores. Vaccine (2012), http://dx.doi.org/10.1016/j.vaccine.2012.09.086 [2] Bach D, et. al.. Transcutaneous immunotherapy via laser-generated micropores efficiently alleviates allergic asthma in Phl p 5–sensitized mice. Allergy 2012; 67: 1365–1374. [3] Weiss R, et. al. Transcutaneous vaccination via laser microporation. J Control Release. 2012 September 10; 162(2): 391–399. doi: 10.1016/j.jconrel.2012.06.031


About Pantec Biosolutions and P.L.E.A.S.E.® Professional

Pantec Biosolutions specializes in precise skin microporation technology. Our proprietary P.L.E.A.S.E.® (Precise Laser EpidermAl SystEm) technology has been developed for:

• Transdermal drug delivery of large molecular weight drugs
• Micro-Poration for intra- or transdermal delivery of various bio-active agents


About the P.L.E.A.S.E.® Platform

P.L.E.A.S.E.® Professional is a multi-application platform with an extendable treatment range for various applications. The platform significantly improves drug uptake in addition to reducing treatment duration, avoiding the need for injections and improving clinical outcome. The technology has significant potential to unlock a high unmet need of treatments requiring large molecular weight biopharmaceuticals.


About P.L.E.A.S.E.® Professional

P.L.E.A.S.E.® Professional Professional is a state of the art bench top laser device that sets new standards for safety, precision and versatility. The advanced user interface and sophisticated software ensures convenient and simple touch-screen operation giving users the option of selecting either pre-stored parameters or customizing parameters themselves.

P.L.E.A.S.E.® Professional is developed and manufactured by Pantec Biosolutions and was awarded a red dot design award in 2010. Pantec Biosolutions is located in Ruggell, Liechtenstein.